内耳免疫反応の平衡機能に及ぼす影響について

抄録

The effect of direct antigen (KLH) challenge of endolymphatic sac (e. sac) on caloric responses was investigated in guinea pigs. Neither caloric responses nor inner ear endorgan was found to be significantly damaged in the primary KLH challenged ears as compared to the unchallenged contralateral ears. Seven days following secondary KLH challenge of the e. sac, caloric responses were significantly suppressed in the challenged ears as compared to the unchallenged contralateral ears. Caloric responses were distinguished into three types which were a) mild-reversible, b) severe-reversible and c) severe-irreversible.
Vacuolization of the sensory hair cells of the lateral crista was seen in the severe-irreversible response type.