The Case was a 80-year-old male. Three years before his first visit, we detected atrophic gastritis and an H. pylori infection during an endoscopy. Both the primary and secondary eradication attempts were unsuccessful.
One year before his first visit, a hyperplastic polyp was detected in a follow-up endoscopy and he started on an oral PPI administration for reflux esophagitis. He was referred to our hospital because the polyp was enlarged to 30 mm.
Eight months after the first visit and after a successful third eradication, the polyp was enlarged to 60 mm. ESD was performed due to suspicion of a malignant tumor complication. The size of the resected lesion was 80 mm × 38 mm. Histopathological findings showed a hyperplastic polyp and no malignant findings were noted.
We report here a case of rapid growing giant gastric hyperplastic polyp, which implies an association between polyp enlargement and hypergastrinemia caused by long-term use of PPI.
