Immunohistochemical Anlysis of Ki-67 exression in so-called SSA/P ; in comparison with hyperplastic polyps

Abstract

It has been proposed by Riddell that sessile serrated adenoma/polyp (SSA/P) with a high degree of cell proliferation exist in the conventional hyperplastic polyp of the colon and rectum. In this article, the purpose of this study was to determine whether cell proliferation of SSA/P is different from that of HP by the use of immunohistochemistory of Ki-67. Fiftysix subjects of HP and classified SSA/P according to three histological feature of the Higuchi’s criteria were assessed by measuring the proliferative compartment with Ki-67 positve cells. The proliferative zone and Labelling index of Ki-67 positeve cells differed siginificantly (p<0.01) between SSA/P and HP. We concluded that this criteria was reasonable to separate from conventional HP to SSA/P in view of cell proliferation.