抄録
A 62-year-old woman with gastric cancer was referred to our hospital for treatment. An esophagogastroduodenoscopy (EGD) revealed a depressed, discolored region 10 mm in diameter at the greater curvature of the lower gastric body. Fundic gland polyps were seen mainly in the middle and upper gastric body, but no atrophy was noted in the background gastric mucosa. The rapid urease test was negative, serum anti-H. pylori antibody was negative (<3.0 U/ml) , and microscopic examination for H. pylori was also negative. These findings suggested carcinogenesis in the absence of H. pylori infection. She was diagnosed with early gastric cancer, type 0-IIc, and underwent laparoscopic-assisted distal gastrectomy. The histopathological diagnosis was signet-ring cell carcinoma, Type 0-IIc, 8×8 mm, pT1a (M) , ly0, v0, pN0 (0/25) , PM0, DM0. In conclusion, almost no atrophic changes occur in the gastric mucosa with fundic polyps, which are very rarely complicated by gastric cancer. However, the occurrence of H. pylori-negative gastric cancer should be kept in mind.
