We encountered a case of duodenojejunal lesion of ulcerative colitis (UC), a 63-year-old woman. 16 years ago, she developed ulcerative pancolitis and underwent total colectomy and ileostomy 3 months ago. Upper abdominal pain appeared 2 months after the surgery and the administration of proton-pump-inhibitors were ineffective. CT showed diffuse edema of the duodenum and jejunum, and enlargement of the mesenteric lymph nodes. Upper gastrointestinal endoscopy showed diffuse granular mucosa from the duodenal bulb to the anal side. We diagnosed her illness as duodenojejunal lesion of UC.
Although administrating crushed Mesalazine, her symptoms worsened and she was hospitalized. After receiving corticosteroid therapy, her symptoms improved and she was discharged.
In this case, her UC was refractory to Mesalazine but steroid therapy was remarkably effective. Although not frequent, ulcerative duodenal lesion should be considered a possible complication of UC.
