Helicobacter pylori除菌効果判定指標としての胃液中尿素濃度測定

抄録

The aim of the present study was to find the usefulness of gastric aspirated urea concentration in detection of the efficacy of eradication of H pylori (HP) by comparing with gastric ammonia concentration and serum pepsinogen I/II ratio.
A total of 32 subjects (15 with gastric ulcer, 15 with duodenal ulcer, and 2 with gastro-duodenal ulcer) were infected with HP. HP infection was detected by microscopic examination of slides stained by Gram's method and treated with Pfeiffer fluid. All patients received lansoprazole (30mg, every morning) and ecabet sodium (2ｇ, twice a day) for 6 or 8 weeks. Patients also received amoxicillin (750mg, three times a day) for last 2 weeks. The clearance and eradication rates were 100% (20/20) and 60% (12/20) , respectivery.
The eradicated group had significantly higher gastric urea and serum pepsinogen I/II levels, and significantly lower gastric ammonia level than before eradication and the non-eradicated group. There were few subjects overlapping in gastric ammonia and serum pepsinogen I/II levels, but no subjects overlapping in gastric urea level in the eradicated and the non-eradicated groups. Measurement of gastric urea level may provide a useful tool for detecting the efficacy of HP eradication.