We reported a case of esophageal squamous cell papilloma treated with endoscopic mucosal resection. A patient was a 41-year-old man who had a flat elevated lesion (40x20mm) with granular surface on the posterior wall of the upper esophagus. Endoscopic resection was performed on February 25, 1993. Histological findings revealed squamous cell papilloma. Immunohistochemistry for human papilloma virus using immunoperoxidase technique was negative. DNA of human papilloma virus in resected specimen (dott blott technique) was negative. HPV infection was excluded.
However, three cases of squamous cell papilloma with malignant changes have been previously reproted. Therefore, a papilloma which size is more than 10mm and one showing the change in size should be actively resected under the endoscopy.
