There are extremely few reports of small cell carcinoma of stomach, although small cell carcinoma occurs to a lung a lot. We report a very rare case of small cell carcinoma of stomach.
A 76-year-old woman, chief complaining of an epigastralgia, visitted our hospital. No abnormalities were found in systemic exermination. An endoscopic approach revealed a Borrmann type 2 tumor at the anterior wall of lesser curvature. The lesion was 5.3×3.0cm in size. The histological diagnosis with biopsy was a well-differentiated adenocarcinoma.
Subtotal gastrectomy was performed. Histologically, the tumor consisted of a differentiated adenocarcinoma and an undifferentiated component. The former was characterized by vaying sizes of solid nests composed of relatively uniform, round cells with numerous mitotic figures. The components were negative to Grimelius, PAS and Alcian Blue stain, NSE, CEA, S-100 protein, Chromogranine. Ultrastructurally, core granules were found in the cytoplasm of a majority of the tumor cells, indicating that our case in a small-cell carcinoma in stomach.
