graft-versus-host diseaseによる胃十二指腸炎の1例

抄録

A 52-year-old female underwent allogeneic bone marrow transplantation because of acute myeloid leukemia. She entered hospital again on suspicion of relapse after 6 months. Prescription of cyclosporin A (cy-A) was ceased to induce graft-versus-leukemia effect.
Therefore graft-versus-host disease (GVHD) of the skin and the liver occured. After a while epigastralgia and nausea appeared. The endoscopic examination revealed candidiasis of the esophagus, diffuse redness in the greater curvature of the stomach and hemorrhagic erosion of the duodenal 2nd portion. The biopsy specimen from stomach and duodenum showed chronic and acute GVHD histologically. Then because the symptom of enteric GVHD was increased, cy-A was prescribed again and later steroid was added to prescribe. As a result the clinical symptom and endoscopic finding of GVHD were improved.
The endoscopic study of enteric GVHD is rare, so we reported this case.