大腸型クローン病の経過観察中に多発性骨髄腫を合併した1例

抄録

A 59-year old female visited our hospital due to diarrhea and body weight loss and was diagnosed as Crohn's disease by colonoscopy in 1988.
In April 1997, the serum immunoglobulin G (IgG) was found to be increased and the immunoelectrophoresis demonstrated“M-peak”. Bone marrow aspiration was performed to show multiple myeloma. Atypical plasma cells were accounted for 15.8% of all bone marrow cells. Although only 2.5mg of prednisolone daily was administered, the serum IgG didn't increase. This case was recognized to start with benign monoclonal hypergammmopathy and develop multiple myeloma.
Only one case has been reported on the relationship between Crohn's disease and multiple myeloma although some cases have been reported on the relationship between multiple myeloma and benign monoclonal gammopathy. Judging from Kyle's report describing that 25% of benign monoclonal gammopathy developed multiple myeloma, this Crohn's disease case might have complicated with benign monoclonal gammopathy from the beginning which developed multiple myeloma.