The patient was a 61-year-old female, who underwent upper gastrointestinal endoscopic exammination because of a positive serum pepsinogen test.
Gastric adenoma was detected in lesser curvature of the gastric corpus, and rectal cancer was also diagnosed by colonoscopy, performed to evaluate iron-deficiency anemia. They were excised endoscopically and surgically, respectively. During following 6 years, duodenal adenoma in the second part of the duodenum, and other gastric adenomas, and another rectal cancer were detected. Some genetic abnormality was supposed, but there was no familial tendency to malignant disease.
We also discussed the possibility that high-risk subjects of gastric neoplasm screened by serum pepsinogen test also belong to the high-risk group of colorectal cancer.
