Bovine Serum Albumin を反復作用させた場合の歯肉の変化に関する研究

抄録

Gross and histological studies were made of gingival responses of multiple challenges due to long term administration of bovine serum albumin (BSA), in view of the findings that generally dental plaque markedly exists in human gingival sulcus resulting in various kinds of antigen acting on periodontal tissue.
The results obtained were as follows:
1. Macroscopical
No changes were found in either Freund's complete adjuvant sensitized or nonsensitized rats.
2. Histopathological
In the sensitized rats infiltration of macrophages and lymphocytes was moderate early in gingival tissue. Little infiltration developed following long term multiple challenges of BSA.
In the nonsensitized rats infiltration of macrophages was moderate in gingival tissue. But after sensitization it was almost absent following the same challenges.
Therefore, when rats were sensitized with BSA, it was suggested that the defensive mechanism might act leading to no damage of tissue following long term multiple challenges of BSA.