2025 Volume 36 Issue 3 Pages 365-371
We report our experience using a dehydrated human amnion/chorion membrane allograft (dHACM), a tissue-healing material recently introduced in Japan, as an adjunctive treatment for refractory ulcers caused by chronic venous insufficiency. Despite standard treatments, including compression therapy and invasive procedures, for superficial venous valve insufficiency, ulcer healing remained insufficient in some cases. Therefore, dHACM was applied as an additional therapeutic approach. In two of four cases, epithelialization was achieved within 43 and 86 days. In contrast, in one case in which treatment adherence decreased, infection occurred, leading to non-healing. Another case of a painful ulcer achieved pain relief following dHACM application, facilitating the continuation of compression therapy and achieving epithelialization within 21 days. dHACM has the potential to enhance healing rates and reduce the treatment duration in refractory venous ulcers when combined with appropriate infection control and compression therapy. However, its effects on deeper tissues and pain reduction require further investigation through accumulation of additional clinical cases.
