抄録
The aim of this study was to ascertain the influence of cysteine derivatives on pro-antioxidant equilibrium and to compare antioxidant effectiveness of N-acetylcysteine, α-lipoic acid and taurine by using Loverro's coefficient (pro-antioxidant ratio) in healthy men exposed to intensity resistance exercise. Fifty-five men were randomly assigned to one of four groups: control (CON, placebo), N-acetylcysteine (NAC 1.8 g·day−1, 3 days), α-lipoic acid (LIP 1.2 g·day−1, 3 days) or taurine (TAU 3 g·day−1, 3 days). The erythrocyte superoxide dismutase (SOD), glutathione peroxidase (GPx) and catalase (CAT) activities, lipid peroxidation products (TBARS) and plasma protein thiols concentrations were evaluated. The P/A ratio was determined from mean values of TBARS, SOD, GPx and CAT. The applied exercise at maximal intensity induced the significant changes in pro-antioxidant equilibrium towards peroxidation which was proved by 25% increase in TBARS concentration in CON group. The peroxidation was significantly diminished by NAC (−14%) and LIP (−16%) whereas TAU did not effect on TBARS concentration. Cysteine derivatives administration prevented exercise-induced decline in SOD activity and increased in GPx activity during exercise. CAT activity changed only in LIP group. The estimation of P/A ratio showed the lowest level of pro-antioxidant equilibrium after LIP administration. In CON group, P/A ratio was directly correlated with protein thiols level (r = 0.495, p < 0.001). These data confirm the antioxidant action of tested cysteine derivatives, particularly lipoic acid, and demonstrate the practical application of P/A ratio to evaluate the effectiveness of antioxidants in athletes.
