抄録
1) Albino rats with their hypophysis and suprarenal glands extirpated produce no initial hyperglycemia even when they are injected with 200mg/kg of xanthurenic acid which in normal rats is capable of causing three stages of changed blood sugar amount. Moreover, when they are thus operated upon and injected with xanthurenic acid, their glycogen amount in the liver is invariably found reduced by half as compared with normal ones.
2) Following the injection of xanthurenic acid, the ascorbic acid amount in the suprarenal glands is found reduced just as in the case of epinephrine injection.?
3) The action of epinephrine can be inhibited by a proper quantity of benzyl-imidazoline, while hyperglycemia can still be noticeably produced by xanthurenic acid even when benzyl-imidazoline is employed simultaneously.
4) The preceding experimental facts lead us to believe that the injected xanthurenic acid directly stimulates the liver itself and prompts the decomposition of carbohydrate; that, simultaneously with it, it acts as “Stressor” and produces the initial hyperglycemia.
