Piroheptine Prevents Loss of 1-Methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)-Induced Striatal Loss of Dopamine in Mice

Abstract

Effect of piroheptine, an anticholinergic agent having a dopamine- uptake inhibiting property, on MPTP-induced striatal loss of dopamine was studied in C57BL/6J mice. Pre-treatment with piroheptine almost completely prevented loss of Striatal dopamine in MPTP-injected mice. Piroheptine is another agent which prevents MPTP neurotoxicity.