Pseudohyphal growth induced by exposure of yeast cells to subinhibitory levels of antifungal azoles in Candida tropicalis.

Takahito Suzuki; Shin-Ichi Iwaguchi; Teijiro Kamihara

doi:10.5685/plmorphol.13.2

Takahito Suzuki, Shin-Ichi Iwaguchi, Teijiro Kamihara

著者情報

キーワード: antifungal agents, Candida tropicalis, pseudohyhal growth

ジャーナルフリー

2001 年 13 巻 1 号 p. 2-10

DOI https://doi.org/10.5685/plmorphol.13.2

詳細

Published: 2001 Received: 2001/12/28 Available on J-STAGE: 2010/06/28 Accepted: - Advance online publication: - Revised: -
訂正情報
訂正日: 2010/06/28 訂正理由: - 訂正箇所: PDFファイル訂正内容: -

訂正日: 2010/06/28 訂正理由: - 訂正箇所: キーワード情報訂正内容: Wrong : Key Words: antifungal agents, Candida tropicalis, pseudohyhal growth
Right : antifungal agents, Candida tropicalis, pseudohyhal growth

訂正日: 2010/06/28 訂正理由: - 訂正箇所: 引用文献情報訂正内容: Wrong : E
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抄録

Summary: The azole class of compounds kills fungal cells through an inhibition of ergosterol biosynthesis resulting in malfunction and breakdown of cell membranes. Subinhibitory levels of these compounds were found bringing about a transition from yeast form to pseudohyphal one in Candida tropicalis, as well as ethanol reported previously. The other classes of inhibitors for ergosterol biosynthesis, terbinafine and amorolfin, also caused the transition. These findings implicated the function of ergosterol for filamentous growth. Although depolarized cell growth was observed to precede filamentation during the process of ethanol-induced pseudohyphal formation in this organism, no distinct depolarization was found to occur during the process induced by these antifungal compounds.

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