Phosphorus Research Bulletin
Online ISSN : 1882-2363
Print ISSN : 0918-4783
ISSN-L : 0918-4783
FORMATION OF INTERMOLECULAR COMPLEX AND POLYMER-DRUG INTERACTION ON THE SURFACE OF HYDROXYAPATITE IN AN AQUEOUS PHASE
SABURO SHIMABAYASHITOMOAKI HINO
著者情報
ジャーナル フリー

2002 年 13 巻 p. 21-30

詳細
抄録
Triton X-100, water-soluble but non-adsorbable to HAP, was adsorbed after formation of a mixed hemimicelle together with SDS. Water-insoluble dye, MY, was incorporated into an SDS aggregate formed on the surface in a similar manner to that of ordinary solubilization performed in an aqueous phase. Water-soluble polymer HPC formed a surface complex of SDS-HPC, which bridged among HAP particles, resulting in flocculation of the particles. Water-soluble MO was captured by BSA adsorbed on HAP, resulting in an increase in its amount of adsorption on the surface of HAP. Mono- and dialkylphosphate was adsorbed to HAP in a similar manner to that of SDS, i.e., after isomorphous substitution. Understanding these phenomena is important for understanding mechanisms of the interaction between drugs and hard tissues and the absorption of drugs into hard tissues as well as the formation of animal hard tissues composed of HAP and organic compounds.
著者関連情報
© Japanese Association of Inorganic Phosphorus Chemistry
前の記事 次の記事
feedback
Top