抄録
Purpose : It is generally accepted that glucocorticoids such as cortisol and hydrocortisone (HYD) promote gluconeogenesis and enhance the degradation of fat and protein. However, it is not clarified whether high levels of glucocorticoids released to blood from adrenal cortex under high stress conditions influence plasma energy substrate levels and extracellular fluid volumes. Therefore, we examined the in vivo effect of HYD on the plasma energy substrate (glucose, triglyceride and total cholesterol) concentrations and hematocrit (Ht) values in rats. Methods : Male SD (7 weeks old, n=16) rats were used. HYD (dose = 5mg/ kg BW) was administered to rats. In the control (CON) rats, a corn oil of an equivalent volume was administered. Results : Plasma glucose concentrations of HYD did not change up to 8 hrs after the administration and were 1.20 times significantly higher than those of CON in 34 hrs. Plasma total cholesterol concentrations of HYD were 1.19-1.29 times significantly higher in 2 to 8 hrs than those of the CON. Plasma triglyceride concentrations of HYD were 0.77-0.71 times significantly lower in 4 to 8 hrs than those of the CON and returned to the beginning level at 34 hrs. Hematocrit values of HYD were 1.06 times significantly higher in 8 to 34 hrs than those of the CON. Conclusion : HYD induces the decline of rat extracellular fluid volumes and mobilization patterns in plasma depend on kinds of the energy substrates. [Jpn J Physiol 54 Suppl:S233 (2004)]
