抄録
To clarify exercise training-mediated alteration in blood vessel tone, the relation between exercise training and human vascular tone was assessed with analyzing alteration in pulsatile arterial function. Arterial pressure pulse waveforms of healthy students (n=182) in Shimane University Faculty of Medicine were recorded by using a modified Windkessel model and characterized waveform morphology to determine large (C1) and small (C2) arterial elasticity compliance during the diastolic portion of the cardiac cycle. Data were compared between students belonging to exercise training clubs (Ex: n=112) and to non-exercise training clubs (NEx: n=70). The values of C1 and C2 of Ex students were 17.2±0.4 mL/mm Hg and 9.2±0.2 mL/mm Hg, respectively, and significantly increased by 6.5% and 14.7% compared with those of NEx students. Diastolic blood pressure and the systemic vascular resistance were significantly lower in Ex students than in NEx students and inversely pulse pressure higher. C2 was positively correlated with diastolic blood pressure. It is suggested that an increase in systemic C2 indicates the improvement of endothelial function on small arterial tone. Data from the students may represent that exercise training has reversible beneficial effects on cardiovascular diseases such as hypertension with endothelial dysfunction accompanied by functional and structural changes that influence arterial stiffness. [Jpn J Physiol 54 Suppl:S240 (2004)]
