抄録
Most of the stereoisomers of D-glucose are rarely found in the nature. Because of the similarities of the structures, these rare sugars are expected to behave like D-glucose, but in some cases, inhibit or strengthen the effect of D-glucose. Obesity is resulted from an excess storage of fat in adipocytes, and is a worldwide health problem associated with serious complications including a high incidence of hypertension, coronary heart disease and type 2 diabetes. Adipocytes synthesize triacylglycerol (TG) from fatty acids and/or sugars, while secreting many kinds of adipocytokine. To estimate the applicability of rare sugars to anti-obesity drugs, we examined the effects of monosaccharides on the properties of adipocytes. METHODS: 3T3-L1 preadipocytes were purchased and differentiated. Three days after the differentiation, nine kinds of monosaccharides including rare sugars were added to the culture medium. The activity of GPDH (glycerol-3-phosphate dehydrogenase) in cytoplasm, the amount of the accumulated TG, and the concentrations of leptin and adiponectin secreted in the culture medium were measured. CONCLUSIONS: D-glucose increased GPDH activity and TG amount, but showed no effect on leptin and adiponectin concentrations. Rare sugars, D-allose, D-psicose and D-altrose, did not increase GPDH nor TG, but slightly decreased the concentration of leptin and/or adiponectin. [J Physiol Sci. 2007;57 Suppl:S243]
