抄録
Peroxisome proliferators-activated receptors alpha (PPARα), the isoform of PPARs, is a transcription factor belonging to the nuclear receptor playing a role in lipid metabolism. It is also reported that the treatment with bezafibrate, which is a PPARα ligand, showed phase-advanced locomotor activity in mice. We examined the effect of the bezafibrate treatment on sleep and body temperature rhythm. Mice were fed with a control diet for two weeks, and were recorded body temperature, electroencephalogram and electromyogram for 48 h, under light/dark conditions. After the baseline recording, these mice were fed with bezafibrate containing diet for 2 weeks, after which the same recordings were carried out. Acrophase of rhythm for locomotor activity and body temperature were about 2 h advanced after 2-week feeding of bezafibrate in comparison with the baseline. Sleep/wake rhythm were also phase-advanced about 3 h. Furthermore, bezafibrate treatment increased the EEG delta power in non rapid eye movement (NREM) sleep compared to the baseline. These data suggest that chronic bezafibrate treatment could advance a sleep/wake and body temperature rhythm as seen in locomotor activity, and PPARα might be involved in the regulation of delta power in NREM sleep. [J Physiol Sci. 2008;58 Suppl:S91]
