抄録
Senescence-accelerated prone (SAMP) mice are model of accelerated aging which was established through phenotypic selection. SAMP8, one of the substrain of SAMP, is known to exhibit an age-related deterioration in learning and memory abilities in comparison to normal aging mice (SAMR1).Same as learning and memory abilities, it is accepted that the age-related deterioration occurs in the sleep-wake states in human and experimental animals. Also in SAMP8 and SAMR1 mice, it is reported that the aging induces the deterioration of sleep-wake architecture and delta power during non-REM sleep both strains. However, the difference between SAMP8 and SAMR1 mice was reported to show only in REM sleep. To confirm the deterioration of sleep architecture in SAMP8 mice in comparison with SAMR1 mice, we carried out the recording of electroencephalogram (EEG) for 24-hour on 10-12 months old SAMP8 and SAMR1 mice. Furthermore, in order to see the homeostatic function, 6-hour sleep deprivation (SD) and the recording during the recovery period from SD were performed. SAMP8 mice showed the significant increase of wakefulness and decrease of non-REM and REM sleep. The delta power during non-REM sleep was attenuated than SAMR1 mice in dark phase. Furthermore, the recovery of delta power induced by 6-hour SD was attenuated in SAMP8 mice.Our results suggest that the sleep architecture and homeostatic control is disturbed in SAMP8 mice in comparison to SAMR1 mice. [J Physiol Sci. 2008;58 Suppl:S91]
