抄録
L-asparaginase was given to total 23 patients with leukemia, malignant lymphoma and the like, and the following results were obtained.
1. Asparaginase, as a remission inducing agent, produced effect especially against acute lymphatic leukemia, malignant lymphoma and malignant ciliated epithelial tumor.
2. Lymphosarcoma and malignant ciliated epithelial tumor which had recurred after remission were treated again with asparaginase and this treatment proved to work well.
3. Slight liver troubles indicated by the rise of GPT or other were frequent during the administration of asparaginase.
4. Examining the variations in level of various amino acids within serum, it was found that there were two types of variations: In one type the level rose rapidly just after the start of administration, then steadily increased. In the order, rising tendency was observed during the whole period of administration of asparaginase and led to high level finally. Glutamic acid, valine, alanine, leucine and isoleucine belong to the former type while methionine, tyrosine and phenylalanine to the latter type.
