Recently some cases of leukemia with hypoplastic preleukemic stage are reported but clinical and statistical observations have not been made. In this paper we have discussed about hematological characteristics of hypoplastic preleukemia and examined its clinical situation between so-called hypoplastic anemia and leukemia. To analyze hypoplastic preleukemia following processes are done.
(i) Studying clinical and hematological findings of 5 cases of leukemia with hypoplastic preleukemic stage
(ii) Studying clinical and hematological findings of 86 cases of hypoplastic anemia and extracting atypical hypoplastic anemia through the statistical examination
(iii) Studying clinical and hematological findings of 10 cases of atypical leukemia with hypoplastic marrow
(iv) Comparing (i)with(ii)
(v) Comparing (i)with(iii)
The present results suggest that hypoplastic preleukemia has two clinical and hematological phases; namely atypical hypoplastic anemia and atypical leukemia and that hypoplastic preleukemia may be the peculiar phase before the terminal developmennt of leukemia. It is also suggested that clinically atypical hypoplastic anemia should be considered as the hypoplastic preleukemic stage, if it is accompanied by some different atypical factors, particularly the appearance of erythroblasts in the peripheral blood, the presence of “Erythroblastenmark” and a slight increase of myeloblasts (more than 3%) in the bone marrow.
