巻号一覧
12 巻 (1971)
- 6 号 p. 513-
- 5 号 p. 417-
- 4 号 p. 335-
- 3 号 p. 207-
- 2 号 p. 61-
- 1 号 p. 1-
12 巻, 2 号
選択された号の論文の9件中1～9を表示しています
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臨床研究
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高橋 功, 長尾 忠美, 石崎 雅信, 木下 日出男, 島田 明人, 喜多島 康一1971 年 12 巻 2 号 p. 61-67
発行日: 1971年
公開日: 2008/10/31
ジャーナル 認証ありRecently some cases of leukemia with hypoplastic preleukemic stage are reported but clinical and statistical observations have not been made. In this paper we have discussed about hematological characteristics of hypoplastic preleukemia and examined its clinical situation between so-called hypoplastic anemia and leukemia. To analyze hypoplastic preleukemia following processes are done.
(i) Studying clinical and hematological findings of 5 cases of leukemia with hypoplastic preleukemic stage
(ii) Studying clinical and hematological findings of 86 cases of hypoplastic anemia and extracting atypical hypoplastic anemia through the statistical examination
(iii) Studying clinical and hematological findings of 10 cases of atypical leukemia with hypoplastic marrow
(iv) Comparing (i)with(ii)
(v) Comparing (i)with(iii)
The present results suggest that hypoplastic preleukemia has two clinical and hematological phases; namely atypical hypoplastic anemia and atypical leukemia and that hypoplastic preleukemia may be the peculiar phase before the terminal developmennt of leukemia. It is also suggested that clinically atypical hypoplastic anemia should be considered as the hypoplastic preleukemic stage, if it is accompanied by some different atypical factors, particularly the appearance of erythroblasts in the peripheral blood, the presence of “Erythroblastenmark” and a slight increase of myeloblasts (more than 3%) in the bone marrow.抄録全体を表示PDF形式でダウンロード (657K) -
苅家 利承, 小沼 宗心, 大橋 辰哉, 吉利 和1971 年 12 巻 2 号 p. 68-74
発行日: 1971年
公開日: 2008/10/31
ジャーナル 認証ありIn uremia the ATP level of the red cell has been known to be increased. The authors have examined the red dell ATP level in various renal diseases (32 cases) and found a high incidence of increased red cell ATP (53.1%), and this level correlated well to the severity of anemia, next to BUN (blood urea nitrogen), plasma inorganic phosphate, but did not correlate to the reticulocyte counts. It is considered that the severity of renal disease might have a profound effect upon the red cell ATP level.
Four out of six patients under peritoneal dialysis showed a decreasc of the red cell ATP level. Some dialysable factor might be responsible for the high ATP level of the red cell.
In uremia, the ATP/ADP ratio was also high in a few instances.
True etiology of the high red cell ATP level in renal diseases in not yet clear, but there might be some abnormality of ATP metabolism in the uremic red cell.抄録全体を表示PDF形式でダウンロード (517K) -
—特にlysosomal enzymeについて—鈴木 厚生, 三浦 亮, 柴田 昭1971 年 12 巻 2 号 p. 75-82
発行日: 1971年
公開日: 2008/10/31
ジャーナル 認証ありThe histochemical studies on some lysosomal enzymes such as acid phosphatase, β-glucuronidase and non-specific esterase in leukemic cells, were carried out. For photomicroscopic techniques azo dye methods using naphthol compounds as substrate were employed, and the ultra-structural localization of acid phosphatase was searched with the metal salt method by Gomori using β-glycerophosphate as substrate, obtaining the following results.
1) In general monocytic leukemia cells showed richer acid phosphatase activity than lymphogenous leukemia cells, but this enzyme activity was found to have considerable variation in acute myelogenous leukemia cells. Therefore, the above mentioned staining technique for this enzyme was not always applicable to the type differentiation of acute leukemia cells.
No apparent relationship was found between this enzyme activiy and morphological characteristics in acute myelogenous leukemia cells.
2) As to to the β-glucuronidase activty almost the same tendency was proved as the acid phosphatase.
3) Depression of either acid phosphatase or β-glucuronidase activity of leukemia cells showed higher possibility for acute myelogenous leukemia than monocytic, and intense activity of either acid phosphatase or β-glucuronidase activity suggested more myelogenous origin than lymphogenous.
4) Monocytic leukemia cells revealed intense naphthol AS acetate esterase activity, which was suppressed conciderably by NaF, whereas acute myelogenous leukemia cells were found to have rather large range of their variation in this activity and its suppression by NaF was also invited to some degree.
The staining of naphthol ASD chloroacetate esterase showed large range of from negative to extremely intense positive in acute myelogenous leukemia cells but weak reaction in all cases of monocytic leukemia.
5) It was revealed by an electron microscopic histochemical method that acid phosphatase activity was not limited to locate in lysosomes. Therefore it could not be concluded that the cells with intense acid phosphatase reaction by means of photomicroscopic histochemical techniques had rich lysosomes.抄録全体を表示PDF形式でダウンロード (933K)
症例
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田中 正夫, 太田 宏, 池田 靖, 堀田 知光1971 年 12 巻 2 号 p. 83-91
発行日: 1971年
公開日: 2008/10/31
ジャーナル 認証ありA Japanese woman aged 53 was admitted on June 14, 1970, with a history of recurrent bout of jaundice associatad with anemia, splenomegaly and dark skin. Splenectomy was performed one year previously, since then she had become deteriously ill and had not responded to the administration of various hematinics such as iron, vitamin B12 and folic acid.
Laboratory examination revealed hyperbilirubinemia (mostly indirect type), elevated serum transaminase and hypersideremia. Peripheral blood smear disclosed, in addition to many nucleated red blood cells, marked anisocytosis and poikylocytosis including target, helmet, and pointed cell. Ineffective erythropoiesis and shortened life span of red blood cells were confirmed by erythrokinetic study.
Significant elevation of hemoglobin F of 6.8% and A2 of 4.3% was found in the hemolysate of the patient and also in that of her son, while no abnormal hemoglobin was detected by conventional hemoglobin analysis.
A diagnosis of β-thalassemia intermedia was made, and the associated hemochromatosis was confirmed by liver biopsy which showed remarkable iron deposition in the liver parenchymal cells.
The pathogenesis of hemochromatosis in association with thalassemia has been reviewed and discussed.抄録全体を表示PDF形式でダウンロード (971K) -
田口 博国, 原 功一, 高橋 功, 真田 浩, 岩崎 一郎, 三村 一, 佐藤 端, 岡本 廸夫, 丹治 康治1971 年 12 巻 2 号 p. 92-97
発行日: 1971年
公開日: 2008/10/31
ジャーナル 認証ありThree cases of vitamin B12 deficiency anemias (megaloblastic anemias) are presented in this report.
The case 1 was a woman of 71 years old, who was diagnosed as pernicious anemia on October 1968. Her serum vitamin B12 level (L. leichimanii) was 50 pg/ml and serum folate level (L. casei) was 45 ng/ml. This high folate level returned normal after the injection of hydroxocobalamin. The case 2 was a man of 62 years old who had been resected his stomach 9 years before admission. His serum vitamin B12 level was 30 pg/ml on May 1969. The serum folate level was 50 ng/ml. After the injection of methylcobalamin, his serum folate level falled rapidly to subnormal level. The case 3 was a 55-year-old woman. Her serum vitamin B12 level on March 1969 was 40 pg/ml and serum folate level was 50 ng/ml. This case was not examined for the serum folate level after the treatment. Discussion is made about the pathogenesis of high serum folate level in pernicious anemia especially concerning about the methyltetrahydrofolate trap hypothesis of Herbert.抄録全体を表示PDF形式でダウンロード (487K) -
山口 潜, 本木 達也1971 年 12 巻 2 号 p. 98-103
発行日: 1971年
公開日: 2008/10/31
ジャーナル 認証ありA 61-year-old clerk was first hospitalized in April 1968 because of fever, rash and general lymphadenopathy of one month's duration. He had been hospitalized under the diagnosis of pulmonary tuberculosis when he was 34 years old.
Examination revealed moderate pallor, non-tender general lymphadenopathy and measles-like rash on the lower abdomen and extremities, but no other abnormal physical findings. Initial laboratory data: Hemoglobin was 8.4 gm/100 ml, PCV 28.5%, reticulocytes 9.9%, leukocytes 12,500 with slight lymphocytosis, and platelets 144,000. A sternal marrow aspiation yielded normocellular material with active erythropoiesis. Urobilinogen was strongly positive in the urine. Serum total protein was 9.6 gm/100 ml with hypergammaglobulinemia; an immunoglobulin determination revealed a simultaneous increase in γG, γM and γA. Direct Coombs' test was positive on repeated occasions. Cold agglutinin titer was always very high, exceeding 1: 2,048. A diagnosis of Hodgkin's disease was made on the finding of the histology of the inguinal lymph node.
Administration of prednisolone resulted in a good response and he left the hospital. He had to return three months later because of right mediastinal pleurisy. Oral administration of Endoxan 100 mg. daily resulted in a good response and he left the hospital on September 28, 1968. Afterwards he was on 50 mg. of Endoxan and 15 mg. of prednisolone daily until January 24, 1969. Fever and lymphadenopathy relapsed at the end of 1968. At the beginning of 1969, anemia progressed and on January 24, 1969 hemoglobin fell to 2.8 gm/100 ml and reticulocytes 0.2% with normal leukocytes and platelets. A sternal marrow aspirate revealed “pure red cell aplasia.” Endoxan was stopped and after two weeks hemoglobin rose up to 8.2 gm/100 ml. He expired on February 17, 1970, after repeated vomiting. The total dose of Endoxan was 9,050 mg.
The clinical diagnosis was confirmed by autopsy. Extensive increase in erythroblasts with maturation arrest was noted in all bone marrow specimens examined.抄録全体を表示PDF形式でダウンロード (986K)
第12回総会
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1971 年 12 巻 2 号 p. 105-142
発行日: 1971年
公開日: 2008/10/31
ジャーナル 認証ありPDF形式でダウンロード (3777K) -
1971 年 12 巻 2 号 p. 143-187
発行日: 1971年
公開日: 2008/10/31
ジャーナル 認証ありPDF形式でダウンロード (4451K)
例会
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1971 年 12 巻 2 号 p. 188-199
発行日: 1971年
公開日: 2008/10/31
ジャーナル 認証ありPDF形式でダウンロード (1190K)
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