臨床研究
Bis (3-mesyloxypropyl) amine p-toluene sulfonate (No 864 T)経口投与による慢性骨髄性白血病の治療経験
1972 年 13 巻 6 号 p. 939-942
詳細
1972 年 13 巻 6 号 p. 939-942
A methancsulfonic acid ester of aminoglycols, bis (3-mesyloxypropyl) amine ptoluenesulfonate used orally was found to be very effective in the treatment of chronic myelogenous leukemia.
1) It was administered daily in a dose of 1 to 2 mg/kg for remission induction and 0.5 to 1 mg/kg for remission maintenance, the dose being adjusted according to blood counts.
2) A complete remission with normal WBC and complete disappearance of splenomegaly was obtained in all of the 9 patients.
3) The agent was used for maintaining complete remissions in 10 patients. Its myelosuppression was, within the dose range employed, granulocyte-specific and less long-lasting than that of busulfan.
4) Side effects was rare and mild; transient upper abdominal discomfort associated with soft stools was noted in 2 patients.
5) As of the end of February, 1972, the median remission period is 19 1/3 months and that of survival 24 1/3 months.
