抄録
A 48-year-old housewife was admitted because of dyspnea, hemorrhagic tendency and severe pains of lower limbs. Hematologic examinations showed severe anemia, thrombocytopenia and leukocytosis with atypical myeloblasts and promyelocytes. A bone marrow specimen revealed a high percentage of leukemic myeloblasts and promyelocytes. The chest X-ray showed marked pleural effusions containing numerous mononuclear cells which had the identical karyotype with leukemic cells in marrow (45, XX, C-, Cq-, D+, G-). A complete remission of five months was induced by combination therapy with prednisolone, 6-mercaptopurine, methotrexate and vincristine, and pleural effusions disappeared completely. Then, relapse occurred with pleural effusions and complete transverse spinal palsy at the 7 th thoracic segment developed suddenly, and the patient died nine months after admission. The postmortem examinations disclosed many tumors composed of leukemic cells, particularly in the dura mater of the spinal cord and bilateral pleurae.
