抄録
Attempts were made to clarify the mechanism and the clinical problems with the pulmonary infarction occurs, from coagulation-fibrinolytic point of view.
1) Consumption of coagulation-fibrinolytic factors was observed at the 3rd to 6th hour after the injection of minced thrombi or Lycopodium spores. With regard to fibrinolytic activity, differences of the response to microembolisation were observed among minced human thrombi, minced rabbit thrombi and Lycopodium spores. Experimental pulmonary infarction could be produced at a high rate through the infusion of blood clots on the 2nd day after the injection of Lycopodium spores, when the coagulation activity was on the highest grade and the fibrinolytic activity was on the lowest grade. We took an interest in the numerical similarity of epidemiological incidence of pulmonary infarction (58% of pulmonary embolism) to the incidence of pulmonary infarction (50 or 56%) obtained from our rabbits experiments through the infusion of blood clots on the 3rd day after the injection of minced thrombi.
2) The coagulation-fibrinolytic pattern in the clinical case tended to be similar to the pattern of rabbits experiments except the pattern of the short time after the infusion of blood clots. Therefore, it was suggested in the clinical case that intravascular coagulation might be already produced before the clinical onset. So that, exsaminations of coagulation-fibrinolytic activity before the clinical onset should be important for clinical treatments.
3) The analysis of coagulation-fibrinolytic activity should be took into the consideration that the examination of the collected venous blood hardly gives the exact information on the local pathological changes.
