抄録
Eight adult patients with acute leukemia were treated with quadruple combination therapy of cyclocytidine, adriamycin, 6 MP and prednisolone. Cyclocytidine (10 mg per kg of body weight per day) and adriamycin (0.6∼0.3 mg per kg of b.w. per day) were administered intravenously by drip-infusion, and 6 MP (2.0∼1.6 mg per kg of b.w. per day) and prednisolone (0.8∼0.6 mg per kg b.w. per day) orally, each for four days. Thereafter no anti-leukemic drug was administered, except for a lower dose of prednisolone. It was thought to be appropriate to institute the next course of therapy from thirty to sixty days after the previous one, until the recovery of the normal hematopoiesis. After two or three courses of therapy, seven patients (four with acute myeloblastic leukemia, two with acute lymphoblastic leukemia and one with acute promyelocytic leukemia) gained a complete remission. Five of them showed almost normal bone marrow morphology. One patient with acute basophilic leukemia gained a partial remission. The complete remission was obtained between 23 and 110 days after the start of the first therapy. So far the duration of remission was two to six months in cases of AML and over ten months in a case of APL.
