抄録
An autopsy case of 40-year-old male with thymic lymphosarcoma is reported. A biopsy specimen of bone marrow showed nodular proliferation of atypical lymphoid cells surrounded by marked leukemoid reaction. Malignant lymphoma was suspected. The tumor cells in the bone marrow showed surface characteristics of T-lymphocytes as determined by spontaneous formation of rosettes with sheep erythrocytes. The tumor was classified as malignant lymphoma of T-cell origin. Shortly before death the lymphoma cells were found in the circulation.
At autopsy, a primary tumor was present in the thymic region. The Hassall's corpuscles were distributed in the tumor tissue. The tumor involved pleura, pericardium, diaphragm and ribs. The metastases were found in bone marrow, kidneys, liver and spleen. The tumor cell infiltration in the spleen was limited to the subendothelial region of trabecular veins. Lymph nodes examined were free of metastasis. Electron microscopic study demonstrated that the tumor cells were composed of immature lymphoid cells with smooth cell surface.
