4. 診断・予後判定・病気の進展とのかかわり

抄録

Using various bandings, studies were performed on human leukemic cell chromosomes. Materials comprised 4 cases with malignant lymphoma (ML), 24 cases with acute leukemia (AL), and 23 cases with chronic myelogenous leukemia (CML).
In cases with ML, there were remarkable changes of chromosome structure in addition to chromosome number, suggesting the occurrence of frequent intrachromosomal rearrangements. In 3 out of 24 cases with AL, C/G- or 8/21-translocation. in one case C (?8) trisomy, and also in one case 1/13 tandem translocation were identified. Reciprocal translocation between chromosomes 9 and 22 was identified in all cases with CML. The break point of the chromosome 22 was either band q11 (21 cases) or probably q12 (2 cases), respectively. Analysis of Q- and C-band polymorphisms suggested the clonal origin of the Ph¹ chromosome. Cytogenetic studies were also performed in blastic crisis of CML, where nummerical or structural changes of chromosome constitution were usually found prior to the clinical signs of blastic crisis.
The present study led to the conclusion that a variety of complex chromosome constitution found in leukemia and solid tumor would originate from a simple chromosomal rearrangement (e. g. 8/21- or 9/22-translocation) via clonal evolution.