抄録
Radiations, chemical agents, viruses and genetic predispositions are considered as possible leukemogenic factors. In this paper authors have demonstrated; 1) a considerablly high frequency of chromosome aberrations of lymphocytes and bone marrow cells in atomic bomb survivors, 2) an existence of chromosome-breaking factor, which damages chromosomes of the normal individuals in the cultures containing the plasma from heavilly exposed survivors, 3) an induction of chromosome aberrations by benzene in the rat bone marrow cells and in the cultures of human lymphocytes, 4) an enhancement of chromosome aberrations of 200 rad irradiation by the treatment of benzene (synergetic effect) and 5) non-parallel relation in Fanconi anemia, an inherited chromosome breakage syndrome, between chromosome aberrations and sister chromatid exchanges induced mitomycin C.
Related with these results, possible relations between leukemogenesis and chromosome aberrations induced by radiations, chemical agents and genetic defect (s) were discussed.
