抄録
A case of primary acquired sideroblastic anemia was described, who died of bone marrow failure after a very short course of illness. The patient, 33 year-old Japanese male, was admitted with a history of anemia of 3 months duration.
On hematological examination at the onset of the disease, marked hyperchromic anemia with the dimorphic pattern of erythrocytes was noted without leukopenia and thrombocytopenia.
Three months later, hematological study revealed the presence of pancytopenia in this patient. Examination of bone marrow disclosed erythroid hyperplasia with minor megaloblastoid change. Iron stores in bone marrow were greatly increased predominantly with ringed sideroblasts. Serum iron was elevated and the ferrokinatic study indicated delayed iron clearance and depressed red cell iron utilization.
Eight months after the admission, the patient died of bleeding in the abdominal cavity. Autopsy revealed hypoplastic bone marrow and the deposition of large amount of hemosiderin in the heart, lungs, liver, spleen, pancreas and kidneys.
