A 55-year-old man was admitted to the hospital because of generalized skin lesions & leucocytosis. Diagnosis of acute myeloid leukemia was made on the hematological examinations and the biopsy of the leukemic skin lesions.
He was treated with multiple combination chemotherapy and leukemic skin lesions disappeared after changing into erythema, papule, nodule, ulcer and so on.
He remained reasonably well on daily maintenance dose of 6-MP, in spite of failure to induce a complete remission. He died from cerebral hemorrhage 13 months after the initial diagnosis.
Specific skin lesions of autopsied leukemia recorded in the “Annual of the Pathological Autopsy Cases in Japan” during the years 1968 through 1975 were analyzed statistically and the following results were obtained.
1) Total number of autopsied cases of leukemia was 7182 and specific skin involvements were showed in 304 cases (4.2% of total autopsied leukemias) including AML 130 (42.8%) MoL 49 (16.2%) CML 48 (15.9%) and so on.
2) Incidence of specific skin involvement in each type of leukemia was as follows: MoL 12.0%, CLL 9.0%, CML 4.8%, ALL 3.9% and AML 3.3%.
