A case of acute lymphoblastic leukemia preceded by neutropenia was reported.
Two years four months old girl was admitted to our hospital for further evaluation of neutropenia. She visited to our clinic because of recurrent infections since her birth and was pointed neutropenia 6 months prior to this admission. Her physical and mental development was normal and had no abnormal physical finding.
Complete blood counts showed hemoglobin 11.6g/dl, WBC 6,800/cmm with 12% of neutrophils and normal platelets count. Bone marrow smear showed normocellularity with 24% of erythroid series, 38% of granuloid series and 12% of lymphoblastoid cells. Myeloid series showed maturation arrest, but no morphorogical abnormalities.
Two months after admission anemia developed gradually. Bone marrow examination showed 90% of lymphoblasts. Patient was treated with vincristine and prednisone and complete remission was induced.
Patient was maintained with 6-MP and VAMP therapy, but expired 3 years after treatment.
