1978 年 19 巻 12 号 p. 1634-1640
The survival and its correlation with initial hematologic values of 169 patients with aplastic anemia were analysed in this study. According to survival terms, these patients could be divided into 3 groups: short-term (≤6 months), intermediate (6 months-5 years) and long-term (≥5 years) survivors. The correlation between the survival terms of the patients and their initial hematologic values were analysed and the usefulness of individual and integrative indices of initial hematologic values (reticulocytes≥1×104/cmm:1, neutrophils≥500/cmm:1, platelets≥3×104/cmm:0.5, and the percentage of hemopoietic cells in bone marrow≥30%:1.5) as prognostic indices was evaluated.
The integrative score of initial hematologic values was found to be a best prognostic indices. According to the integrative score, the severity of the disease was classified into 3 groups: severe (score 0∼2), moderate (score 2.5∼3.5) and mild (score 4).
As the patients with score 1 or less have extremely poor prognosis under the conventinal treatment, bone marrow transplantation will be recommended as an another therapeutic approach for these patients at this time, if they have a HLA compatible donor(s).