A 61-year-old male patient was admitted to our hospital because of melena and abdominal discomfort. On admission, anemia and hepatomegaly were noted. Hematological examinations showed leukocytosis with a low score of neutrophil alkaline phosphatase. Chromosome studies of bone marrow and peripheral blood without PHA revealed to have a cell line with 45, X, Ph1. However, the banding karyotope of peripheral lymphocytes, cultured for 48 hours with PHA, showed 46, XY, normal pattern. He was diagnosed as having Ph1-positive chronic myelogenous leukemia with missing Y. Duodenal ulcer was detected by the fiber gastroscope.
