Two cases of fulminant hepatitis, associated with aplastic anemias in remission stage, were reported. One patient who had been diagnosed as having congenital aplastic anemia at the age of 4 months showed the fulminant hepatitis at the age of 2 years and died after 4 days of treatments. Serum HBs antigens were negative.
Another patient who had been diagnosed as having idiopathic aplastic anemia at the age of 5 years showed the fulminant hepatitis at the age of 10 years and died after 10 days of treatments. He had no HBs antigens. The postmortem examination of his liver revealed submassive necrosis caused by viral hepatitis.
Fourteen out of twenty-four cases of aplastic anemias observed at this department during the last 14 years were found having liver dysfunctions. Four cases were caused by viral hepatitis, one case was caused by toxic hepatitis, nine cases were caused by side effects of anabolic steroid hormones.
Seven out of fourteen patients died, because of hepatic failures (two cases), bleedings (three cases), pneumonia (one case), and traffic accident (one case).
Patients with liver dysfunctions which had been caused by side effects of anabolic steroid hormones have recovered spontaneously after stopping or decreasing of the drugs, except in one case.
