抄録
In order to investigate the disturbances of central nervous system (CNS) in acute childhood leukemias, EEG records were performed in 41 children suffering from acute leukemias. They were divided into non-CNS-involving (CNS (-) group: 25 cases) and CNS-involving group (CNS ⊕ group: 24 cases). In 24 cases of CNS ⊕ group, increased cell counts in CSF were observed in 13 cases, clear CSF were observed in 6 cases and lumbar punctures were not performed in 5 cases.
The results were as follows:
1) EEG abnormalities were seen in 56.0% of CNS (-) group, and in 83.3% of CNS ⊕ group.
2) Focal signs in EEGs were seen in 14 of 24 cases of CNS ⊕ group, and in 4 of 25 cases of CNS (-) group. Thrce of the 4 cases who revealed focal signs in EEGs in CNS (-) group, developed CNS-leukemias later. (Two cases developed within 1 month, and 1 case developed 12 months later.)
3) The diffuse low voltages in EEGs were commonly seen in the cases treated with vincristine and prednisolone.
4) EEG records were performed in 5 cases treated with Methotrexate (MTX) intrathecal injections and in 3 cases treated with 60Co whole skull irradiations, before and after treatments for CNS-involvements. EEGs, as well as clinical symptomes, showed marked improvements in 6 cases but a slight aggravation was observed in 1 case treated with MTX.
