抄録
Fourteen patients with “leukemic” non-Hodgkin's lymphoma were studied on clinical manifestations and pathologic findings.
A term “leukemic” was defined as histologically proved lymphoma with more than 5% neoplastic cells in bone marrow and positive neoplastic cells in peripheral blood.
Since lymphosarcoma in childhood and youngster with mediastinal mass becomes very frequently “leukemic” at the time when lymphadenopathy is still localized, those patients should be separated as “leukemic type” from stage IV of Ann Abor staging classification.
Autopsy findings showed huge profound lymphadenopathy and massive infiltration of neoplastic cells in the liver, spleen, bone marrow, kidney, lung, and other organs, despite of regressed superficial lymphadenopathy and improved hematology data. Major cause of death was severe systemic hemorrhage.
Eight patients with “leukemic” non-Hodgkin's lymphoma were treated with intensive combination chemotherapy with Adriamycin, Cyclophosphamide, Vincristine, and Prednisolone (ACVP Therapy). Three complete and three partial remissions were observed for a duration of 20∼90 days with repeated ACVP Therapy. Of major side effects including alopetia, numbness, GI disorders, leucopenia and thrombocytopenia, severe leucopenia could be a limiting factor of ACVP Therapy.
Serum LDH level correlated well to therapeutic effects.
