A 34-year-old man was transferred to our hospital because of nausea, vomiting, fever, anuria and generalized lymphadenopathy on July 13, 1976, and died on the 240th hospital day. The histological diagnosis of axillary lymph node biopsy was reticulum cell sarcoma. On admission laboratory findings were as follows: Hb 10.1g/100ml, Ht 29.7%, WBC 8,200 (Neutro 97%, Lymph 2%), platelet 3.6×104, BUN 208mg/dl, creatinine 7.9mg/dl, uric acid 42mg/dl, Ca 6.7mg/dl, P 9.0mg/dl, PTH 1.1mg/dl. A chest roentgenogram shortly after admission showed diffuse bilateral reticulonodular shadow. He was treated with hemodialysis for acute renale failure, and with COP-Arac, Adriamycin, Bleomycin and radiation for reticulum cell sarcoma. Postmorten examination revealed the infiltrations of tumor cells in lymph nodes and kidney, and the marked calcium depositions in lung, heart and kidney. The parathyroid glands showed questionable hyperplasia of the chief cells. Pathogenesis and mechanisms of metastatic calcification have been discussed.
