A 44-year-old man was admitted with chief complaint of painless tumor in the face. Since March 1974, he has had the tumor with neither pain nor itching, but in March 1975, he was pointed out eosinophilia by a doctor and required scrupulous examination. Physical examination showed no remarkable findings except for the presence of the tumors in the right cheek, cervical, axillar, elbow and inguinal regions. Examination of the peripheral blood disclosed marked eosinophilia, 5,940/cmm at the peak. Sternal marrow aspiration revealed moderate increase of eosinophilic series. Bone survey and laboratory data of blood chemistries, urine and stool are all within normal limits. Histological study of the tumor showed marked hyperplasia of lymph follicles with germinal center and infiltrations of lymphocyte and eosinophils.
A diagnosis of soft tissue eosinophilic granuloma was made and administration of 600mg of oxyphenbutazone daily was started. The response was good and the dose of the drug was tapered. Treatments for soft tissue eosinophilic granuloma with oxyphenbutazone and others in the literatures were discussed.
