1. 慢性骨髄性白血病における染色体変化

抄録

122 patients with chronic myelogenous leukemia were cytogenetically studied. 107 out of 122 patients were examined during the chronic phase and 47 both in chronic phase and in blastic phase.
The results were as follows:
1) All of them but one patient had Ph¹ chromosomes.
2) During the chronic phase 4 patients had autosomal anomalies such as 46, XY, Bq+, Ph¹ and 46, XX, Dq-, Ph¹, and 3 had the lack of a Y chromosome.
3) Abnormal karyotypes other than Ph¹ chromosome were found in the spleen cells from patients even in the early phase of the disease.
4) About 80% of patients in blastic phase showed chromosome abnormalities in addition to Ph¹ chromosome.
5) Some patients with chromosome abnormalities other than Ph¹ chromosome in the chronic phase were found to have the same abnormal karyotype in the blastic crisis.
6) 47 patients who had transformed to blastic phase were studied on possible relationship between chromosome aberrations and clinical types of blastic crisis. Blastic crisis was categorized into 4 types from the clinical and laboratory findings; abrutive type, accelerated type, type of tumor-formation, and type of “without chronic phase.” Most of the patients with tumor formation showed hyperdiploidy and double Ph¹ chromosome. Patients with accelerated type of blastic crisis had a tendency to have pseudodiploidy.
7) There was no relations between the total dose of busulfan and type of chromosome aberrations at the time of blastic crisis.
These results, along with other findings reported in literatures, indicate that Ph¹ positive cells involve primarily some nature to convert to other additional chromosome aberrations other than Ph¹ at any stage of the disease.
Possible trial of chemotherapy for chronic myelogenous leukemia was discussed.