抄録
It has been recognized that coagulation and fibrinolysis play the pathogenic roles in renal diseases. In this paper, the activities and antigenicities of the natural occurring inhibitors of coagulation and fibrinolysis in plasma such as AT-III, α2-macroglobulin, α1-antitrypsin and Ci esterase inactivator were measured and the clinical significance was analysed. It was found that the levels of these plasmatic inhibitors were not correlated with the renal histological findings, but particularly AT-III was increased in cases of nephrotic syndrome and diabetic nephropathy, which suggested that the levels of these inhibitors may reflect the pathological stadium, irrespective of the types of these diseases.
To a case of SLE with nephrotic syndrome with decreased platelet count, low fibrinogen level and low AT-III level, the administration of prednisolone as well as heparin resulted into correction of these abnormalities and clinical improvement. The similar pattern to this abnormality was found immediately after the induction of experimental Masugi nephritis in dog.
It was concluded that the hypercoagulable state was strongly suggestive in cases with this abnormal coagulation pattern, and the anticoagulant therapy must be indicated together with the other treatments of renal diseases.
