抄録
The changes of natural clotting and fibrinolytic inhibitors in collagen and collagen like diseases were reported. Natural clotting and fibrinolytic inhibitors were estimated by means of single radial immunodiffusion method. Total antithrombin activity was measured by fibrin agarose plate procedure. The relationship between the levels of enzymatic activities and antigenicity in plasminogen were expressed as UK and SK index; i. e. SK index=the level of Eug+SK/plasminogen amounts and UK index=the level of Eug+UK/plasminogen amounts
The results obtained were as follows:
1. In many cases of SLE with active phase, the high levels of antithrombin III, α1antitrypsin and C1 inactivator were shown. The values of antiplasmin and α2macroglobulin remained within normal limits. In the index of SK and UK, a tendency to the decrease was also observed.
2. The discrepancy between the activity and antigenicity of antithrombin III was seen in 2 cases of 12 SLE with active phase. From those findings, it could be suggested that secondary molecular like disease of antithrombin III were presented.
3. In Eug fraction of normal adults, mean values of C1 inactivator amounts were shown to be about 60%. In a case of SLE with active phase, that was about 40%. It could be proved that the low levels of UK and SK index in SLE cases with active phase were due to the influence of high levels of C1 inactivators amounts in those Eug fraction.
