抄録
A case of acquired sideroblastic anemia in a 70-year-old Japanese male was reported.
He was admitted to Tokai University Hospital in October 1976, because of anemia and neuralgia in the left maxillary and mandibulary region. Peripheral blood showed partial hypochromic anemia. Serum iron was elevated and ferrokinetic study indicated increased rate of iron clearance and depressed red cell iron utilization. Examination of bone marrow revealed erythroblastic hyperplasia. Sideroblasts were markedly increased and 74% of them were ringed ones. In electron microscopic examination, a large quantity of iron was demonstrated in mitochondria surrounding nucleus of erythroblasts. The degenerative changes of mitochondria in either erythroblasts or granulocytes were found.
Both the activity of δ-aminolevulinic acid synthetase in erythroblasts and the activity of neutral protease and cytochrome oxidase in granulocytes were greatly reduced.
The pathogenetic significance of these deficient enzyme activities in sideroblastic anemia was discussed.
