抄録
Thirty-one adult patients with acute non-lymphocytic leukemia entered the chemotherapy protocol study. They had had no chemotherapy previously. Among them, sixteen patients were treated with DCTP two step therapy, composed of daunomycin (DNR), cytosine arabinoside (Ara-C), 6-thioguanine (6TG) and prednisolone. The other fifteen patients were treated with DCMP two step therapy, composed of DNR, Ara-C, 6-mercaptopurine (6MP) and prednisolone.
The incidence of complete remission was 68.8% in DCTP two step therapy and 66.7% in DCMP two step therapy, respectively, but 80% in both groups among patients under the age of 60.
With regards to side effects during these therapies, liver dysfunction occured in 40% of the patients and gastrointestinal bleeding in 26%. There were no differences between two regimens.
The high incidence of complete remission obtained in these two step therapies can be partly accounted for by the capability of having reduced leukemia cells remarkably through the 1st step therapy of DCMP or DCTP two step therapy.
