Autologous bone marrow transplantation (Auto-BMT) was carried out a 27 year old man with stage IV malignant lymphoma of 4 months' duration. This procedure was performed under bioclean room therapy, after high dose cyclophosphamide (CY), 120 mg/kg and 1,000 rad total-body irradiation (TBI). The autologous marrow was removed 2 months before BMT, gradually frozen in the anticryopreservation and kept in liquid nitrogen until use. Just before use, the cryopreserved marrow was thawed rapidly, 2 times washed and intravenously infused to the patient. Sequential blood study showed WBC of 0 on day +5, but WBC of over 1,000 on day +21. He has survived from gangrenous stomatitis and acute hepatitis by intensive supportitive therapy such as hyperalimentation, fractionated blood transfusion, intravenous immunoglobulin, etc. He is now healthy with no chemotherapy, approximately 6 months after BMU. This is the first successful cases in Japan of Autp-BMT aimed to cure the patient. In summation, to malignant tumors with no marrow invasion by tumor cells and with hypersensitivity to drugs or TBI, Auto-BMT would be the most potential therapeutic weapon.
