抄録
Blood viscosity is clinically important as to the blood circulation and coagulation.
The effect of Dextran on the blood viscosity and the variation of the whole blood and plasma viscosity were measured before and after operation. The viscosity was measured by ‘VISCONIC’ (Tokyo Keiki Co.)
Dextran infusion decreased hamoconcentration and whole blood viscosity, experinentally and clinically, and a significant positive correlation was observed between the hematocrit and blood viscosity, but no significant correlation was noted between fibrinogen and whole blood viscosity.
The effect of Dextran on the blood viscosity was due not only to the hemoconcentration but also to the viscosity of red cells. Namely, red cell viscosity was measured after the incubation of red cells with Dextran or saline. Red cell viscosity after the incubation with Dextran, was clearly lower as compared with that after the incubation with saline.
According to electron microscopic examination, the morphology of the red cells after the incubaiton with Dextran was changed after the incubation with saline distinctly. Red cells became more smooth, after Dextran incubation and rough after saline incubation.
The variation of blood viscosity was investigated at the time of pre-operation, the postoperative days 1, 3 and 7. The whole blood viscosity was increased after the operation, especially on the postoperative 7 days, but plasma viscosity did not change.
From the above results, we postulate that postoperative high blood viscosity promotes the postoperative hypercoagulable state, and so the effect of Dextran on the blood viscosity inhibits the postoperative hypercoagulable state.
